From "Another Horseman Saddles Up to Supernatural"
Famine, step aside. Following the stomach-turning cannibalistic introduction of the third of of the Four Horseman of the Apocalypse on last week's Supernatural, the just renewed CW hit is searching for a 40-50 year old man to play Pestilence. This latest Horseman is described as quirky, unassuming and highly intelligent. Oh, he's also a bit neurotic and has a..a...ha-choo! A cold! Nasty!
Since Pestilence is defined as "a fatal, usually fatal epidemic disease," we can expect our Winchester brothers to be challenged by Pestilence's smarts as he attempts to carry out a diabolical plan of bio-terrorism. Stock up on the Cold-Eeze!
Also complicating matters will be a character from Sam's Stanford years named Tyson, who is now working for a pharmaceutical company and has plans to capitalize on a disgusting flu virus by providing the vaccine.